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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
09:17

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

Treatment of otitis media caused by Hemophilus influenzae: evaluation of three antimicrobial regimens

S H Sell, D A Wilson, J M Stamm

    Southern Medical Journal
    |December 1, 1978
    PubMed

    Insights

    A combination of erythromycin ethylsuccinate and trisulfapyrimidines proved effective for treating children with Hemophilus influenzae otitis media, matching ampicillin efficacy.

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Pharmacology

    Background:

    • Otitis media is a common childhood infection.
    • Hemophilus influenzae is a frequent causative agent.
    • Antimicrobial resistance necessitates evaluating treatment efficacy.

    Purpose of the Study:

    • To compare the efficacy of three antimicrobial regimens for otitis media caused by Hemophilus influenzae.
    • To evaluate ampicillin, erythromycin ethylsuccinate, and a combination of erythromycin ethylsuccinate with trisulfapyrimidines.

    Main Methods:

    • Prospective, double-blind study involving ninety children.
    • Tympanocentesis confirmed Hemophilus influenzae infection.
    • Treatment groups received ampicillin, erythromycin ethylsuccinate, or combination therapy.

    Main Results:

    • The combination regimen was as effective as ampicillin.
    • Combination therapy was statistically superior to erythromycin ethylsuccinate alone.
    • Some treatment failures occurred despite in vitro sensitivity, suggesting complex factors in clinical response.

    Conclusions:

    • Erythromycin ethylsuccinate with trisulfapyrimidines is a viable treatment option for Hemophilus influenzae otitis media.
    • Clinical outcomes may not always correlate with in vitro sensitivity.
    • Further research into treatment response variability is warranted.

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