Related Experiment Video
Updated: Jan 25, 2026

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model
Published on: July 12, 2018
EAST1 toxin: An enigmatic molecule associated with sporadic episodes of diarrhea in humans and animals
1Faculté de médecine vétérinaire, Université de Montréal, Montréal, Québec, J2S 2M2, Canada. daniel.dubreuil@umontreal.ca.
Abstract:
EAST1 is produced by a subset of enteroaggregative Escherichia coli strains. This toxin is a 38-amino acid peptide of 4100 Da. It shares 50% homology with the enterotoxic domain of STa and interacts with the same receptor. The mechanism of action of EAST1is proposed to be identical to that of STa eliciting a cGMP increase. EAST1 is associated with diarrheal disease in Man and various animal species including cattle and swine. Nevertheless, as EAST1-positive strains as well as culture supernatants did not provoke unequivocally diarrhea either in animal models or in human volunteers, the role of this toxin in disease is today still debated. This review intent is to examine the role of EAST1 toxin in diarrheal illnesses.
More Related Videos
08:16Combining Behavior and EEG to Study the Effects of Mindfulness Meditation on Episodic Memory
Published on: May 11, 2020
09:39Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
Published on: May 30, 2013
Related Concept Videos
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Animal Mitochondrial Genetics
Molecules and Compounds
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
The binding of dantrolene to the RYR1...
Tonicity in Animals