The top 10 research priorities in bleeding disorders: a James Lind Alliance Priority Setting Partnership

Bleeding in fresh concrete occurs when water from the mix rises to the surface. This happens because the mix's solid components fail to retain all the water as they settle, leading to separation where water collects at the top. The severity of bleeding can be measured by assessing the total settlement or by noting the decrease in height per unit height of concrete.
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...

The James-Lange theory of emotion, proposed by William James and Carl Lange in the late 19th century, asserts that emotions are the result of physiological reactions to external stimuli. Contrary to the traditional view, which suggests that emotions directly arise from the perception of stimuli, this theory proposes that emotions occur as a consequence of the body's responses to such stimuli. According to this framework, an emotional experience is a cognitive interpretation of physiological...

Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...

The setting time of cement refers to the process of cement paste transitioning from a plastic state to a solid state. This process is crucial in construction as it dictates the timeframe for concrete placement, compaction, and finishing. The onset of this solidification is termed the initial set, indicating when the paste becomes unworkable. The final set is when the paste has solidified completely, and further handling or manipulation can no longer affect its shape. The cement strength is...

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...