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Primary liver graft dysfunction and non-function: integrative literature review.

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Liver graft dysfunction occurs in 7-27% of patients, with primary non-function in 1.4-8.4%. Understanding terminology and risk factors improves post-liver transplant survival.

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Area of Science:

  • Hepatology
  • Transplant Surgery
  • Clinical Research

Background:

  • Focus in liver transplantation has shifted from waitlist mortality to post-transplant graft survival and function.
  • Standardized terminology and understanding of risk factors for graft dysfunction are needed.

Purpose of the Study:

  • To review and standardize terminology for liver graft dysfunction and non-function.
  • To investigate the incidence and risk factors associated with these events.

Main Methods:

  • Integrative literature review of studies published between 2012-2016.
  • Searched databases including CINAHL, MEDLINE, Cochrane, LILACS, BDENF, IBECS, EMBASE, and Web of Science.
  • Selected 14 relevant studies.

Main Results:

  • Hepatic graft dysfunction incidence ranged from 7% to 27%, described as initial malfunction, hypofunction, marginal function, or delayed function.
  • Primary non-function of liver grafts occurred in 1.4% to 8.4% of patients, termed early dysfunction or graft loss.
  • Identified risk factors related to donor, recipient, graft, and transplant logistics.

Conclusions:

  • Knowledge of diverse terminologies for liver graft dysfunction and primary non-function is crucial.
  • Understanding incidence and risk factors aids in event control and improves patient survival post-liver transplantation.