Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kinetic Energy00:23

Kinetic Energy

43.2K
Kinetic energy is the ability of an object in motion to do work or enact change. It can take on many forms. For instance, water flowing down a waterfall has kinetic energy. In biological systems, particles of light travel and are absorbed by plants to create chemical energy. Animals consume the chemical energy and give off molecules that carry their scent through the air. They also generate kinetic energy when they run away from predators. Entire systems also possess kinetic energy, like the...
43.2K
Enzyme Kinetics01:19

Enzyme Kinetics

103.9K
Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
103.9K
Kinetic Molecular Theory: Molecular Velocities, Temperature, and Kinetic Energy03:07

Kinetic Molecular Theory: Molecular Velocities, Temperature, and Kinetic Energy

29.8K
The kinetic molecular theory qualitatively explains the behaviors described by the various gas laws. The postulates of this theory may be applied in a more quantitative fashion to derive these individual laws.
29.8K
The Thoracic Cage: Sternum01:17

The Thoracic Cage: Sternum

5.9K
The thoracic or rib cage forms the body's thorax (chest) portion. Its primary function in the body is to protect vital organs in the thoracic cavity, such as the heart and the lungs. It consists of 12 pairs of ribs with their costal cartilages and the sternum. The ribs are anchored posteriorly to the 12 thoracic vertebrae (T1-T12).
The sternum is the elongated bony structure on the anterior side of the thoracic cage. It consists of three parts: the manubrium, the body, and the xiphoid...
5.9K
The Thoracic Cage: Ribs01:20

The Thoracic Cage: Ribs

8.4K
Ribs are curved, flattened bones forming the thoracic cavity wall with the thoracic muscles. There are 12 pairs of thoracic ribs. The posterior ends of all the ribs articulate with the T1–T12 thoracic vertebrae. In contrast,the anterior ends of most ribs attach to the sternum via their costal cartilages.
Parts of a Typical Rib
A typical rib has a head, neck, and body. The posterior end of the rib is called the head, followed by a narrow neck. The head articulates primarily with the costal...
8.4K
Elimination Kinetics: First-Order and Zero-Order01:05

Elimination Kinetics: First-Order and Zero-Order

2.8K
Eliminating drugs from the body is a vital process that occurs through excretion or metabolism. Understanding the kinetics of drug elimination is crucial for drug development, dosage determination, and optimizing patient outcomes.
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is a drug's half-life, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring synthetic routes to 6-functionalized 4-azaspiro[2.3]hexanes.

Organic & biomolecular chemistry·2026
Same author

Potent and biased agonists of class B1 GPCRs from a heterochiral design strategy.

Nature chemistry·2026
Same author

Overcoming inconsistent DNA extraction recovery across tissue types in qPCR assays supporting biodistribution studies.

Bioanalysis·2026
Same author

Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain.

Nature communications·2025
Same author

Optimizing multifunctional fluorescent ligands for intracellular labeling.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Blood-brain-barrier permeable fluorescent astrocyte probes.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jan 25, 2026

Murine Left Anterior Descending LAD Coronary Artery Ligation: An Improved and Simplified Model for Myocardial Infarction
10:39

Murine Left Anterior Descending LAD Coronary Artery Ligation: An Improved and Simplified Model for Myocardial Infarction

Published on: April 2, 2017

26.0K

Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics.

Pratik Kumar1, Omar Zainul1, Frank M Camarda1

  • 1Department of Chemistry , Stony Brook University , Stony Brook , New York 11790 , United States.

Organic Letters
|April 25, 2019
PubMed
Summary

New activatable cyclopropenes offer faster reactions with s-tetrazines. This improved modular activation strategy enhances bioorthogonal chemistry applications.

More Related Videos

Modified Technique for Coronary Artery Ligation in Mice
05:47

Modified Technique for Coronary Artery Ligation in Mice

Published on: March 29, 2013

26.5K
Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

56.2K

Related Experiment Videos

Last Updated: Jan 25, 2026

Murine Left Anterior Descending LAD Coronary Artery Ligation: An Improved and Simplified Model for Myocardial Infarction
10:39

Murine Left Anterior Descending LAD Coronary Artery Ligation: An Improved and Simplified Model for Myocardial Infarction

Published on: April 2, 2017

26.0K
Modified Technique for Coronary Artery Ligation in Mice
05:47

Modified Technique for Coronary Artery Ligation in Mice

Published on: March 29, 2013

26.5K
Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

56.2K

Area of Science:

  • Organic Chemistry
  • Chemical Biology
  • Materials Science

Background:

  • Activatable cyclopropenes are key reagents in bioorthogonal chemistry, enabling selective reactions under physiological conditions.
  • Their reactivity is controlled by masking groups, allowing for modular activation strategies.
  • Inverse electron demand Diels-Alder reactions with s-tetrazines are crucial for bioconjugation.

Purpose of the Study:

  • To develop a next-generation activatable cyclopropene scaffold.
  • To enhance the ligation kinetics of cyclopropenes with s-tetrazines.
  • To maintain the modularity of activation strategies.

Main Methods:

  • Synthesis of novel cyclopropene derivatives with a new core scaffold.
  • Evaluation of activation strategies using light- and enzyme-cleavable protecting groups.
  • Kinetic studies of the inverse electron demand Diels-Alder reaction between activated cyclopropenes and s-tetrazines.

Main Results:

  • A new cyclopropene scaffold was successfully synthesized.
  • The modular activation strategy was preserved.
  • Ligation kinetics with s-tetrazines were improved by up to 270-fold compared to first-generation cyclopropenes.

Conclusions:

  • The developed cyclopropenes represent a significant advancement in activatable cyclopropene technology.
  • The enhanced ligation kinetics broaden the applicability of these cyclopropenes in complex biological systems.
  • This work provides more efficient tools for bioorthogonal chemistry and bioconjugation.