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Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics
Pratik Kumar1, Omar Zainul1, Frank M Camarda1
1Department of Chemistry , Stony Brook University , Stony Brook , New York 11790 , United States.
Abstract:
Activatable cyclopropenes are unreactive toward their inverse electron demand Diels-Alder reaction partner (e.g., s-tetrazines) until they are activated. The activation strategy is highly modular due to the cyclopropene's ability to be caged by various light- and enzyme-activatable groups. This work describes the next generation of activatable cyclopropenes with a new core scaffold that maintains the activation modularity of the first generation but improves upon the ligation kinetics with s-tetrazines by ≤270-fold.
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