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Transfer of Cyclobenzaprine into Human Milk and Subsequent Infant Exposure
Bhaskari Burra1, Palika Datta2, Kathleen Rewers-Felkins2
11 School of Medicine, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
Introduction:
Cyclobenzaprine is a skeletal muscle relaxant primarily used in the treatment of pain. Its use during lactation is a matter of concern as its level of exposure to infants through human milk is still unknown.
Main Issue:
The aim of this study was to determine cyclobenzaprine concentrations in the milk samples collected from two lactating mothers.
Management:
The present study describes the analysis of cyclobenzaprine in human milk using liquid chromatography mass spectrometry, which determined the drug concentration-time profiles in human milk.
Conclusion:
This study shows low levels of concentrations of cyclobenzaprine in human milk with calculated relative infant dose of 0.5%. However, due to the sedative properties of cyclobenzaprine, regular clinical assessment of the infant is recommended to evaluate for long-term effects.
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