Assessment of volatile methylsiloxanes in environmental matrices and human plasma

Volatile methylsiloxanes (VMSs) are widely used in various personal-care products and industrial additives and products. This study focused on VMSs exposure in the general population, workers, and the families of workers living in residential and industrial areas of southwestern China. VMSs concentrations in indoor environmental matrices from six industrial facilities were 3.4 × 10² to 9.0 × 10² μg m^-3 in gas-phase samples, 4.7 × 10² to 1.5 × 10⁴ μg g^-1 in PM_2.5 samples, and 2.3 × 10² to 7.2 × 10³ μg g^-1 in dust samples, which were two to four orders of magnitude higher than the concentrations measured in residential areas. Exposure to VMSs was investigated by analysis of plasma samples from workers in residential and industrial areas for the presence of cyclic (D4-D6) and linear (L3-L16) VMSs. VMSs concentrations in plasma samples ranged from 84 to 2.3 × 10² ng ml^-1 in workers, one to two orders of magnitude higher than those in the general population (2.2 ng ml^-1). Daily VMSs indoor exposure via inhalation and ingestion in individuals from residential and industrial areas were estimated and assessed under working-time and leisure-time conditions. This study showed that exposure to VMSs in industrial areas is approximately two to four or one to two orders of magnitude higher than that in residential areas during the working- or leisure-time scenario, respectively. Furthermore, the families of workers (the non-occupational group) experienced higher levels of exposure to VMSs in their homes compared with the general population. The ratios of exposure to linear VMSs via PM_2.5 inhalation to that via the gas phase ranged from 7.8% to 43.1% in industrial areas. This study suggests that intake of linear VMSs via PM_2.5 inhalation should be considered when estimating human exposure to VMSs in areas with high levels of PM_2.5 air pollution.