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Non-Coding RNAs as New Therapeutic Targets in the Context of Renal Fibrosis

Cynthia Van der Hauwaert1,2, François Glowacki3,4, Nicolas Pottier5,6

  • 1EA 4483-IMPECS-IMPact of Environmental ChemicalS on Human Health, Univ. Lille, 59045 Lille CEDEX, France. cynthia.vanderhauwaert@gmail.com.

International Journal of Molecular Sciences
|April 26, 2019
PubMed

Insights

This review explores non-coding RNAs, specifically microRNAs (miRNAs), in kidney fibrosis. These molecules show promise as therapeutic targets and biomarkers for chronic kidney disease.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Genetics

Background:

  • Fibrosis, or tissue scarring, involves excessive extracellular matrix accumulation after chronic injury.
  • Renal fibrosis signifies end-stage kidney disease, leading to irreversible function decline.
  • Current therapeutic options for renal fibrosis are limited, with poorly understood mechanisms.

Purpose of the Study:

  • To review recent advances in understanding non-coding RNAs in kidney fibrosis.
  • To discuss the potential of microRNAs (miRNAs) as therapeutic targets and biomarkers.
  • To explore future research directions and clinical applications.

Main Methods:

  • Literature review of seminal studies on non-coding RNAs and kidney fibrosis.
  • Analysis of recent scientific findings on miRNA roles in renal fibrosis.
  • Synthesis of information on diagnostic and therapeutic potential.

Main Results:

  • Non-coding RNAs, particularly miRNAs, play a significant role in kidney fibrosis.
  • miRNAs are emerging as crucial regulators in the development of renal fibrosis.
  • These molecules offer potential as biomarkers and therapeutic targets.

Conclusions:

  • miRNAs represent a promising area for novel therapeutic strategies in renal fibrosis.
  • Further research into miRNAs could lead to improved diagnostics and prognostics for kidney disease.
  • Understanding miRNA involvement is key to developing effective treatments for renal fibrosis.
Keywords:
biomarkerslong non-coding RNAsmicroRNAsnon-coding RNAsrenal fibrosistherapeutics targets

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