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Updated: Jan 25, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
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Peripheral Microvascular Function Reflects Coronary Vascular Function.

Ahmed Al-Badri1, Jeong Hwan Kim1, Chang Liu1

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Arteriosclerosis, Thrombosis, and Vascular Biology
|April 26, 2019
PubMed
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Peripheral vascular endothelial function correlates with coronary endothelial function, suggesting systemic endothelial health can be assessed non-invasively. This finding aids in understanding atherosclerosis development and cardiovascular risk.

Keywords:
acetylcholineblood flow velocityendotheliumnitroprussidevascular resistance

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Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Diagnostic Cardiology

Background:

  • Coronary endothelial dysfunction precedes atherosclerosis and adverse cardiovascular outcomes.
  • The systemic versus localized nature of human endothelial dysfunction remains unclear.
  • Assessing peripheral vascular function may offer insights into coronary health.

Purpose of the Study:

  • To investigate if peripheral (femoral) vascular endothelial function reflects coronary vascular endothelial function.
  • To determine the correlation between peripheral and coronary responses to vasoactive agents.
  • To evaluate the utility of peripheral measurements in assessing coronary endothelial function and coronary flow reserve.

Main Methods:

  • Simultaneous measurement of femoral and coronary vascular function in 85 subjects undergoing coronary angiography.
  • Utilized intracoronary and intrafemoral infusions of acetylcholine (endothelium-dependent) and sodium nitroprusside (endothelium-independent).
  • Assessed coronary flow reserve using intracoronary adenosine and measured flow velocity with a Doppler wire.

Main Results:

  • A modest correlation was found between femoral and coronary endothelial function.
  • Femoral endothelial function changes with acetylcholine correlated with coronary vascular resistance and epicardial artery diameter changes.
  • Coronary vasodilator response to adenosine correlated with femoral vasodilation induced by acetylcholine.

Conclusions:

  • Peripheral microvascular endothelial function is modestly correlated with coronary epicardial and microvascular function.
  • Peripheral vascular endothelial function assessment may serve as a surrogate for evaluating coronary endothelial function and coronary flow reserve.
  • Findings suggest endothelial dysfunction may be a generalized phenomenon in the human vasculature.