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Impact of hepatitis C sustained viral response on cardiovascular diseases: a meta-analysis

Kamolyut Lapumnuaypol1, Charat Thongprayoon2, Karn Wijarnpreecha3

  • 1Department of Internal Medicine, Albert Einstein Medical Center , Philadelphia , PA , USA.

Hospital Practice (1995)
|April 26, 2019
PubMed

Insights

Achieving Sustained Virologic Response (SVR) after Hepatitis C virus (HCV) treatment significantly lowers the risk of cardiovascular disease (CVD). This finding highlights the cardiovascular benefits of successful HCV treatment.

Area of Science:

  • Hepatology
  • Cardiology
  • Infectious Diseases

Background:

  • Hepatitis C virus (HCV) infection is linked to increased cardiovascular disease (CVD) risks.
  • The impact of HCV treatment on cardiovascular outcomes is not well-established.

Purpose of the Study:

  • To systematically review and meta-analyze the effect of Sustained Virologic Response (SVR) on cardiovascular outcomes in patients with chronic HCV infection.

Main Methods:

  • A systematic review of MEDLINE, EMBASE, and Cochrane databases was performed.
  • Seven cohort studies comprising 53,841 patients were included.
  • Random-effect meta-analysis was used to combine effect estimates.

Main Results:

  • Patients achieving SVR showed a reduced risk of overall CVDs (Hazard Ratio: 0.76, 95% CI: 0.61-0.94).
  • The average follow-up period was 5 years.
  • No publication bias was detected using Egger's regression test.

Conclusions:

  • Sustained Virologic Response following HCV treatment is associated with a significant reduction in overall cardiovascular disease risk.
  • Successful HCV treatment offers cardiovascular protection.

Keywords:
HCV treatmentSVRcardiovascular diseasemeta-analysis; hepatitis C

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