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Updated: Jan 25, 2026

Author Spotlight: RNAi Inheritance and ChIP in C. elegans
Published on: May 5, 2023
Transgenerational Epigenetic Inheritance Is Revealed as a Multi-step Process by Studies of the SET-Domain Proteins
Rachel M Woodhouse1, Alyson Ashe1
1School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia.
Abstract:
It is now clear that heredity is not determined purely by Mendelian genetic inheritance; sometimes, epigenetic signals can be passed from parent to progeny for multiple generations. This phenomenon is termed transgenerational epigenetic inheritance (TEI), and examples have now been observed in multiple organisms including plants, flies, mice, and nematodes. Here we discuss the recent findings that TEI is a multi-step process and that the putative chromatin modifiers SET-25 and SET-32 are important in the establishment but not maintenance of silencing.
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