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Updated: Jan 25, 2026

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Published on: December 1, 2023
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Exercise in people with comorbidity or multimorbidity.
Joost Dekker1, Bianca M Buurman2, Marike van der Leeden3
1Department of Psychiatry.
Summary
Exercise is safe and effective for individuals with multiple health conditions (comorbidity or multimorbidity). Key principles include health assessment, exercise adaptation, behavior change integration, and clinical reasoning for developing exercise guidance.
Area of Science:
- Exercise Science
- Clinical Medicine
- Rehabilitation
Background:
- Exercise offers significant health benefits but lacks specific guidance for individuals with comorbidity or multimorbidity.
- Current exercise guidelines cater to healthy individuals or those with a single disease, leaving a gap for complex patient populations.
Purpose of the Study:
- To identify the fundamental principles for applying exercise in individuals managing comorbidity or multimorbidity.
- To establish a framework for developing tailored exercise guidance for complex health conditions.
Main Methods:
- A narrative review was conducted on existing research concerning exercise interventions in individuals with comorbidity or multimorbidity.
- The review synthesized findings to extract core principles guiding exercise application in these populations.
Main Results:
- Effective exercise for comorbidity or multimorbidity necessitates rigorous health status assessment.
- Exercise plans must be adapted to the specific combination of health conditions.
- Integration of behavior change techniques is crucial for adherence and success.
- Clinical reasoning by health professionals is essential for safe and effective exercise prescription.
Conclusions:
- Four core principles—assessment, adaptation, behavior change, and clinical reasoning—form a foundation for exercise guidance in complex conditions.
- These principles offer a framework to develop evidence-based exercise recommendations for individuals with comorbidity or multimorbidity.
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