Related Experiment Video
Updated: Jun 12, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 14, 2016
Quinolone derivatives and their antifungal activities: An overview
1School of Chemistry and Life Science, Anshan Normal University, Anshan, Liaoning, P.R. China.
Abstract:
More than 300 million people suffer from the incidence of life-threatening invasive fungal infections, resulting in over 1.35 million deaths annually. Currently, the antifungal agents available in clinics are rather limited, and the rapid development of resistance to the existing antifungal drugs has further aggravated mortality. Quinolones possess a broad spectrum of chemotherapeutic properties and demonstrate considerable antifungal activities as well. Various quinolone derivatives have been screened for their antifungal activities, and some of them exhibit excellent potency against both drug-susceptible and drug-resistant fungi. This review aims to outline the recent advances in quinolone derivatives as potential antifungal agents and summarize the structure-activity relationship, to provide insights for the rational design of more active candidates.
Related Concept Videos
Antihypertensive Drugs: Thiazide-Class Diuretics
Gene Regulation in Microbial Communities: Quorum Sensing
Inhibitors of Bacterial DNA Synthesis
Antiviral Nucleoside Inhibitors
Antifungal Agents
Anthelminthic Agents

