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Development of peripheral B and T lymphocytes in piglets
Zeitschrift Fur Immunitatsforschung. Immunobiology
|September 1, 1978
Summary
Piglet peripheral blood B and T lymphocytes increase significantly after birth. These immune cells reach adult levels by weaning, indicating developmental maturation in young swine.
Area of Science:
- Immunology
- Veterinary Science
- Developmental Biology
Background:
- Peripheral blood lymphocyte populations are crucial for immune function.
- Understanding lymphocyte dynamics in neonatal animals is vital for assessing immune competence.
Purpose of the Study:
- To quantify the ontogeny of B and T lymphocytes in piglets during the first 35 days of life.
- To establish reference ranges for lymphocyte populations in neonatal and young swine.
Main Methods:
- Immunofluorescence assays using anti-L chain sera.
- Spontaneous E-rosette techniques for T lymphocyte identification.
- Flow cytometry analysis of peripheral blood mononuclear cells.
Main Results:
- B lymphocyte percentages showed a linear increase from 4% in newborns to adult levels.
- T lymphocyte percentages followed a bimodal pattern, starting at 3% and changing by day 10.
- Adult pig peripheral blood lymphocyte values were established as benchmarks.
Conclusions:
- Piglets demonstrate significant increases in B and T lymphocyte populations during early life.
- Lymphocyte development suggests immune system maturation by the weaning stage.
- This study provides essential data for evaluating swine health and immunity.