Related Experiment Video
Updated: Aug 13, 2026
12:58
A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Long-term experience with combined action of antibacterials
Czechoslovak Medicine
|January 1, 1986
Summary
Amoxicillin with clavulanic acid effectively controls pediatric respiratory infections, including pneumonia, shortening treatment duration. In vitro studies also confirmed high synergistic action between ticarcillin and aminoglycosides.
Area of Science:
- Pediatric infectious diseases
- Pharmacology and therapeutics
Background:
- Respiratory infections are common in children.
- Pneumonia is a significant concern in pediatric respiratory infections.
- Antibiotic resistance necessitates evaluating combination therapies.
Purpose of the Study:
- To evaluate the efficacy of amoxicillin-clavulanic acid in treating respiratory infections in children aged 3-9 years.
- To assess the impact of this combination on treatment duration.
- To investigate the in vitro interaction between ticarcillin and aminoglycosides.
Main Methods:
- Clinical application of amoxicillin-clavulanic acid in pediatric patients.
- In vitro susceptibility testing of ticarcillin and aminoglycosides.
Main Results:
- Amoxicillin-clavulanic acid demonstrated good results in controlling respiratory infections, particularly pneumonia.
- Appropriate use of the combination therapy led to a shortened treatment period.
- High synergistic action was observed between ticarcillin and tested aminoglycoside preparations in vitro.
Conclusions:
- Amoxicillin-clavulanic acid is effective for treating pediatric respiratory infections, including pneumonia.
- Optimized antibiotic selection can reduce treatment duration.
- Ticarcillin and aminoglycosides exhibit significant synergy, suggesting potential for combined therapeutic use.
More Related Videos
Related Concept Videos
01:27Combined Effects of Drugs: Synergism
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
01:31Defense Against Bacterial Pathogens
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
01:28Pulmonary Tuberculosis V
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
01:28Antimicrobial Effectiveness
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
01:30Development of Antibiotic Resistance
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...