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Abuse potential evaluation of inhalants.

R L Balster

    Drug and Alcohol Dependence
    |January 1, 1987
    PubMed
    Summary

    Inhalant abuse is a global issue, but specific compound risks are unclear. This review explores laboratory methods, like animal self-administration and discrimination studies, to assess inhalant abuse potential for public health strategies.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Public Health

    Background:

    • Inhalant abuse represents a significant global drug abuse challenge.
    • There is a lack of comprehensive understanding regarding the abuse liability of specific inhalant compounds.
    • Existing research has not fully elucidated the comparative risks associated with different inhalants.

    Purpose of the Study:

    • To review laboratory methodologies for investigating the abuse potential of inhalant substances.
    • To highlight the importance of animal studies in assessing drug abuse liability.
    • To identify research gaps and advocate for further investigation into inhalant abuse potential.

    Main Methods:

    • Focus on laboratory-based approaches, particularly animal models.
    • Discussion of inhalant self-administration paradigms.
    • Consideration of drug discrimination assays for evaluating subjective effects.

    Main Results:

    • Animal self-administration studies can quantify the reinforcing properties of inhalants.
    • Drug discrimination studies can assess the capacity of inhalants to serve as discriminative stimuli.
    • These methods provide a framework for comparative analysis of different inhalant compounds.

    Conclusions:

    • Further research is crucial to determine the relative abuse potential of specific inhalants.
    • Data from laboratory investigations can inform public health policies and interventions.
    • A better understanding of inhalant abuse liability is needed for effective prevention and treatment strategies.

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