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Bio-compatible patient-specific elastic bolus for clinical implementation.

Jong Min Park1,2,3,4, Jeaman Son1,3, Hyun Joon An1,3

  • 1Department of Radiation Oncology, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Physics in Medicine and Biology
|April 26, 2019
PubMed
Summary
This summary is machine-generated.

Dragon Skin, a flexible silicone rubber, is ideal for 3D printing patient-specific elastic boluses. It offers superior biological stability and dosimetric accuracy for radiation therapy applications.

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Area of Science:

  • Biomaterials Science
  • Medical Physics
  • Radiation Oncology

Background:

  • Patient-specific boluses are crucial in radiation therapy for dose conformity.
  • Developing biocompatible and physically stable bolus materials is an ongoing challenge.
  • 3D printing offers potential for creating customized radiation therapy devices.

Purpose of the Study:

  • To evaluate silicon rubber (Dragon Skin) and urethane liquid rubber (Clear Flex 30) for 3D printed patient-specific boluses.
  • To assess the biological, physical, and dosimetric properties of these materials.
  • To determine the suitability of Dragon Skin for clinical implementation as a bio-compatible patient-specific elastic (BPE) bolus.

Main Methods:

  • Mold casting and direct 3D printing methods were used to manufacture boluses.
  • Materials evaluated included Dragon Skin, Clear Flex 30, and NinjaFlex.
  • Biological (cytotoxicity, skin irritation/sensitization), physical (flexibility, durability), and dosimetric properties were assessed using elaborate human phantoms.

Main Results:

  • Dragon Skin demonstrated the highest biological stability and excellent physical properties (Shore hardness 10A, 475 psi tensile strength, 1000% elongation).
  • Dragon Skin boluses exhibited minimal differences between calculated and measured surface doses and reduced air gaps.
  • NinjaFlex was used for direct printing, while Dragon Skin and Clear Flex 30 were used for mold casting.

Conclusions:

  • Dragon Skin is a suitable material for creating bio-compatible patient-specific elastic (BPE) boluses.
  • The material's properties support its effective implementation in clinical radiation therapy settings.
  • 3D printed boluses using Dragon Skin can improve dose accuracy and patient treatment.