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Updated: Jan 25, 2026
Establishing Fungal Entomopathogens as Endophytes: Towards Endophytic Biological Control
Published on: April 11, 2013
Structural Identification of Antibacterial Lipids from Amazonian Palm Tree Endophytes through the Molecular Network
Morgane Barthélemy1, Nicolas Elie2, Léonie Pellissier3
1CNRS-Institut de Chimie des Substances Naturelles, UPR2301, Université Paris-Saclay, 91198 Gif-sur-Yvette CEDEX, France. morgane.barthelemy@cnrs.fr.
Abstract:
A library of 197 endophytic fungi and bacteria isolated from the Amazonian palm tree Astrocaryum sciophilum was extracted and screened for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Four out of five antibacterial ethyl acetate extracts were also cytotoxic for the MRC-5 cells line. Liquid chromatography coupled to tandem mass spectrometry (UPHLC-HRMS/MS) analyses combined with molecular networking data processing were carried out to allow the identification of depsipeptides and cyclopeptides responsible for the cytotoxicity in the dataset. Specific ion clusters from the active Luteibacter sp. extract were also highlighted using an MRSA activity filter. A chemical study of Luteibacter sp. was conducted leading to the structural characterization of eight fatty acid exhibiting antimicrobial activity against MRSA in the tens of µg/mL range.
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