[Effect of prostaglandin E2 on the secretory function of the stomach]

The effect of prostaglandin E2 (PgE2) injected with histamine in dogs with stomach fistula, involved a decrease of volume of secreted gastric juice, production of hydrochloric acid and pepsin lessening as compared with the findings obtained in the effect of histamine alone. The inhibition of gastric secretion increases in combined injection of PgE2 with histamine and acetylcholine. After intramuscular injection of PgE2 the content of sodium ions in the blood serum of rats decreases, the concentration of potassium becoming higher. In the mucose membrane of stomach the content of sodium and potassium increases; oxygen pressure in the mucous membrane of stomach decreases after the injection of PgE2.