Related Experiment Video
Updated: Aug 2, 2026
08:46
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
Clomiphene citrate response is predictable in corpus luteum insufficiency
Summary
Predicting clomiphene citrate dosage for corpus luteum insufficiency is now possible. A study of 117 patients showed predictable responses to 100 mg daily clomiphene citrate, indicated by a threefold progesterone increase.
Area of Science:
- Reproductive Endocrinology
- Pharmacology
Background:
- Corpus luteum insufficiency affects fertility.
- Accurate clomiphene citrate dosing is crucial for effective treatment.
Purpose of the Study:
- To evaluate clomiphene citrate treatment outcomes in corpus luteum insufficiency.
- To determine if clomiphene citrate sensitivity is predictable.
Main Methods:
- Radioimmunoassay (RIA) was used to measure serum progesterone and prolactin.
- Treatment outcomes for 117 patients were analyzed.
Main Results:
- A threefold increase in serum progesterone was observed after 100 mg/day clomiphene citrate.
- This progesterone increase was independent of initial progesterone or prolactin levels.
Conclusions:
- Clomiphene citrate sensitivity is predictable in selected, hormonally homogeneous patient groups.
- This finding contrasts with earlier observations and aids in precise dosing.
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