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Published on: June 6, 2025
Use of sliding transphyseal flexible intramedullary nailing in pediatric osteogenesis imperfecta patients
Insights
Flexible intramedullary nailing corrects deformities in severe osteogenesis imperfecta. While effective, it has high complication and reoperation rates, though the Ilizarov frame improves stability.
Area of Science:
- Orthopedics
- Pediatric Orthopedics
- Biomaterials Engineering
Background:
- Osteogenesis imperfecta (OI) is a genetic disorder causing bone fragility.
- Severe OI often requires surgical intervention for skeletal deformities.
- Flexible intramedullary nailing (FIN) is a treatment option for pediatric bone deformities.
Purpose of the Study:
- To assess the outcomes of sliding flexible intramedullary nailing (FIN) in severe osteogenesis imperfecta (OI) in children.
- To compare FIN alone versus FIN combined with the Ilizarov frame for deformity correction.
Main Methods:
- Retrospective review of 17 pediatric patients with severe OI (types III, IV, VII).
- Group I: Transphyseal FIN using titanium nails (9 patients).
- Group II: Sliding FIN combined with Ilizarov frame (8 patients).
Main Results:
- Group I (FIN alone) had an 88.9% complication rate and 100% reoperation rate.
- Common complications in Group I included nail migration, torsional displacement, and non-telescoping.
- Group II (FIN + Ilizarov frame) had a complication rate of 75% and a reoperation rate of 87.5%.
Conclusions:
- Flexible intramedullary nailing effectively realigns bones and improves function in severe OI.
- High complication and reoperation rates are significant disadvantages of FIN.
- The Ilizarov frame offers added stability and enables earlier weight-bearing when combined with FIN.
Abstract:
In our country, the sliding Flexible Intramedullary Nailing is used alone or in combination with Ilizarov frame in children with osteogenesis imperfecta. The study assesses the results of sliding intramedullary nailing in deformity correction in severe types of osteogenesis imperfecta. We retrospectively reviewed 17 consecutive cases (mean age 5.2 y.o.) of types III, IV and VII of osteogenesis imperfecta. In group I (9 patients) the transphyseal FIN was performed using titanium nails. Sliding flexible intramedullary nailing was associated with Ilizarov frame in group II in 8 children. Patients in group I had overall complication rate of 88.9%: proximal nail migration (3), early secondary torsional displacement (4), non-telescoping (12), angular deformity (2), delayed or non-union (2). The reoperation rate was 100%. In group II we observed complications in 6 patients: nail migration (2), bowing of femur (2), non-telescoping (3). The reoperation rate was 87.5%. Flexible intramedullary nailing allows realignment and good functional outcomes. Its major disadvantage is an important complication rate and related reoperation rate. The use of Ilizarov frame provides additional stability and allows early weight-bearing.
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