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Updated: Jan 25, 2026
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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
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White Matter Correlates of Cognitive Performance on the UCSF Brain Health Assessment
Andrea G Alioto1, Paige Mumford2, Amy Wolf3
1Alzheimer's Disease Center- East Bay,University of California,Davis, CA 94598,USA.
Summary
White matter microstructure impacts memory and executive functions in older adults. Specific white matter tracts, like the fornix and corpus callosum, are linked to distinct cognitive abilities, offering insights into cognitive aging.
Area of Science:
- Neuroscience
- Gerontology
- Radiology
Background:
- White matter (WM) microstructural changes are linked to cognitive differences in aging.
- Understanding these changes is crucial for identifying mechanisms of cognitive decline.
Purpose of the Study:
- To investigate the relationship between white matter microstructure patterns and cognitive performance in older adults.
- To examine associations between fractional anisotropy (FA) in specific WM tracts and performance on memory, executive function, and visuospatial tasks.
Main Methods:
- Examined 84 older adults (healthy, mild cognitive impairment, dementia).
- Assessed fractional anisotropy (FA) in white matter tracts and cognitive performance using the UCSF Brain Health Assessment (BHA).
- Used regression analyses to evaluate relationships between FA and cognitive subtests, controlling for global FA.
Main Results:
- Memory performance correlated with FA in the fornix and superior cerebellar peduncle.
- Executive functions and speed correlated with FA in the body of the corpus callosum.
- Neither global nor tract-specific FA related to visuospatial performance.
Conclusions:
- Distinct white matter microstructural patterns are associated with memory and executive functions.
- Findings contribute to understanding white matter alterations in age-related cognitive decline and dementia.
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