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The effects of cranberry on cardiovascular metabolic risk factors: A systematic review and meta-analysis

Makan Pourmasoumi1, Amir Hadi2, Ameneh Najafgholizadeh3

  • 1Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Clinical Nutrition (Edinburgh, Scotland)
|April 27, 2019
PubMed
Abstract

Insights

Cranberry supplements may help manage systolic blood pressure and body mass index in adults. Younger adults may also see benefits in high-density lipoprotein levels with cranberry intake.

Area of Science:

  • Nutritional Science
  • Cardiovascular Health
  • Metabolic Syndrome Research

Background:

  • Cardiovascular disease (CVD) poses a significant global health challenge.
  • Metabolic risk factors contribute substantially to CVD development.
  • Dietary interventions, including supplementation, are explored for CVD risk management.

Purpose of the Study:

  • To systematically evaluate the efficacy of cranberry supplementation.
  • To assess impacts on key metabolic risk factors for cardiovascular disease.
  • To analyze findings in diverse adult populations.

Main Methods:

  • Conducted a systematic review and meta-analysis.
  • Searched major scientific databases (PubMed, Scopus, Web of Science, Google Scholar) up to June 2018.
  • Included randomized controlled trials (RCTs) investigating cranberry supplementation and cardiovascular metabolic risk factors.

Main Results:

  • Cranberry supplementation significantly reduced systolic blood pressure (SBP) and body mass index (BMI).
  • No significant changes were observed in lipid profiles (triglycerides, total cholesterol, LDL, HDL), glucose metabolism, or inflammatory markers.
  • SBP reduction was more pronounced in older adults (≥50 years); HDL increased and triglycerides decreased in younger adults (<50 years) and with juice consumption, respectively.

Conclusions:

  • Cranberry supplementation shows potential for managing SBP, BMI, and HDL in younger adults.
  • Evidence suggests specific benefits for certain metabolic factors in defined age groups.
  • Further high-quality research is warranted to confirm these findings and elucidate mechanisms.
Keywords:
Cardiovascular diseaseCranberryMeta-analysisVaccinium macrocarpon

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