Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hydroxychloroquine for pre-exposure prophylaxis of COVID-19 in health care workers: a randomized, multicenter, placebo-controlled trial Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine (HERO-HCQ).

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2023

Same author

Risk of hemolysis in Plasmodium vivax malaria patients receiving standard primaquine treatment in a population with high prevalence of G6PD deficiency.

Infection·2022

Same author

Effectiveness of Severe Acute Respiratory Syndrome Coronavirus 2 Monoclonal Antibody Infusions in High-Risk Outpatients.

Open forum infectious diseases·2021

Same author

Pancytopenia and Profound Neutropenia as a Sequela of Severe SARS-CoV-2 Infection (COVID-19) With Concern for Bone Marrow Involvement.

Open forum infectious diseases·2021

Same author

SARS-CoV-2 Infection (COVID-19) and Herpes Simplex Virus-1 Conjunctivitis: Concurrent Viral Infections or a Cause-Effect Result?

Cureus·2021

Same author

Efficacy and Safety of a Naphthoquine-Azithromycin Coformulation for Malaria Prophylaxis in Southeast Asia: A Phase 3, Double-blind, Randomized, Placebo-controlled Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2020

Same journal

Canaliculitis associated with multiple retained silicone punctal plugs and concurrent biodegradable plug placement.

BMJ case reports·2026

Same journal

Bilateral vocal cord paralysis in multifocal motor neuropathy.

BMJ case reports·2026

Same journal

Multiple visceral artery aneurysms and type II Abernethy malformation in a patient with autoimmune hepatitis.

BMJ case reports·2026

Same journal

Congenital nasolacrimal duct cyst complicating as an orbital abscess.

BMJ case reports·2026

Same journal

Management of <i>Achromobacter xylosoxidans</i> bacteraemia with an atypical antimicrobial resistance pattern.

BMJ case reports·2026

Same journal

Unintentional chronic acetaminophen overuse as an under-recognised cause of liver injury.

BMJ case reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 25, 2026

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Published on: December 8, 2023

Recalcitrant Paecilomyces keratitis.

Seetha Lakshmi¹, Cristina Vanessa Garcia¹

¹Department of Infectious Disease, University of South Florida, Tampa, Florida, USA.

BMJ Case Reports

|April 27, 2019

Summary

This summary is machine-generated.

A rare fungal corneal ulcer caused by Paecilomyces species in a contact lens wearer was successfully treated with antifungal agents and surgery. Recurrence occurred after treatment cessation, necessitating prolonged therapy.

Keywords:

infectious diseases ophthalmology

More Related Videos

Hybrid-Cut: An Improved Sectioning Method for Recalcitrant Plant Tissue Samples

Hybrid-Cut: An Improved Sectioning Method for Recalcitrant Plant Tissue Samples

Published on: November 23, 2016

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

Related Experiment Videos

Last Updated: Jan 25, 2026

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Published on: December 8, 2023

Hybrid-Cut: An Improved Sectioning Method for Recalcitrant Plant Tissue Samples

Hybrid-Cut: An Improved Sectioning Method for Recalcitrant Plant Tissue Samples

Published on: November 23, 2016

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

Area of Science:

Ophthalmology
Mycology

Background:

Corneal ulcers can lead to significant vision loss.
Fungal keratitis is a serious ocular infection, particularly in contact lens wearers.

Observation:

A 54-year-old woman presented with a 4-week corneal ulcer after contact lens use.
Culture identified Paecilomyces species, with associated corneal edema and hypopyon.
Visual acuity in the affected eye was significantly reduced to finger counting.

Findings:

Initial treatment involved topical/systemic antifungals and surgical intervention (intrastromal amphotericin B, conjunctival flap).
Near-complete resolution was achieved after 3 months, but recurrence happened 3 weeks post-therapy cessation.
Prolonged antifungal therapy (6 months) was reinstituted with regular monitoring.

Implications:

Paecilomyces species represent a challenging cause of fungal keratitis.
Aggressive treatment, including surgical intervention and prolonged antifungal therapy, may be necessary.
Close monitoring is crucial to prevent recurrence of fungal corneal ulcers.