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Related Experiment Video

Updated: Jan 25, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Plant-Based Diets and Incident CKD and Kidney Function.

Hyunju Kim1,2, Laura E Caulfield1, Vanessa Garcia-Larsen1

  • 1Center for Human Nutrition and.

Clinical Journal of the American Society of Nephrology : CJASN
|April 27, 2019
PubMed
Summary
This summary is machine-generated.

Adhering to healthy plant-based diets may lower chronic kidney disease (CKD) risk and slow kidney function decline. Less healthy plant-based diets were linked to increased CKD risk.

Keywords:
AtherosclerosisDietDiet, VegetarianFollow-Up StudiesPlant-based diet indicesProportional Hazards ModelsRenal Insufficiency, Chronicchronic kidney diseaseglomerular filtration ratekidneykidney functionvegetarian diet index

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Area of Science:

  • Nephrology
  • Nutritional Science
  • Epidemiology

Background:

  • The relationship between plant-based diets and chronic kidney disease (CKD) in the general population remains under-examined.
  • Previous research has not extensively evaluated how different types of plant-based diets influence CKD incidence and kidney function.
  • This study addresses this gap by investigating plant-based dietary patterns and their association with kidney health.

Purpose of the Study:

  • To prospectively examine the association between various plant-based diet indices and the risk of developing incident CKD.
  • To evaluate the relationship between plant-based diets and the rate of kidney function decline, measured by estimated glomerular filtration rate (eGFR).
  • To determine if the risk of CKD varies based on the healthfulness of the plant-based diet consumed.

Main Methods:

  • A prospective, population-based study involving 14,686 middle-aged adults from the Atherosclerosis Risk in Communities (ARIC) study.
  • Dietary intake was assessed using four distinct plant-based diet indices: overall, healthy, provegetarian, and less healthy.
  • Cox proportional hazards models and linear mixed models were employed to analyze associations with incident CKD and eGFR decline, adjusting for potential confounders.

Main Results:

  • Higher adherence to a healthy plant-based diet (HPBD) and a provegetarian diet was associated with a significantly lower risk of incident CKD.
  • Conversely, greater adherence to a less healthy plant-based diet (LHPBD) was linked to an elevated risk of CKD.
  • Increased consumption of HPBD and overall plant-based diets correlated with a slower decline in eGFR over the follow-up period.
  • Approximately 4.1% of CKD cases were attributable to lower adherence to HPBD.

Conclusions:

  • Higher adherence to healthy plant-based diets and provegetarian diets is associated with reduced risk of developing chronic kidney disease.
  • These dietary patterns are also linked to a slower rate of kidney function decline.
  • The findings suggest that emphasizing healthier plant-based food choices can be beneficial for kidney disease prevention and management.