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Updated: Jan 25, 2026

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
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UHRF genes regulate programmed interdigital tissue regression and chondrogenesis in the embryonic limb

Cristina Sanchez-Fernandez1, Carlos I Lorda-Diez1, Juan A García-Porrero1

  • 1Departamento de Anatomía y Biología Celular and IDIVAL, Universidad de Cantabria, 39011, Santander, Spain.

Cell Death & Disease
|April 27, 2019
PubMed
Summary

Epigenetic regulators Uhrf1 and Uhrf2 control embryonic limb development by promoting cell senescence and apoptosis. These genes fine-tune the balance between cell stemness and differentiation, crucial for programmed cell death during digit formation.

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