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Interactions of antimicrobial agents and antineoplastic agents
The Journal of Antimicrobial Chemotherapy
|December 1, 1986
Summary
This study investigated drug interactions between antimicrobials and antineoplastics against Gram-negative bacilli. Piperacillin showed significant synergism, while antagonism was rare, suggesting potential combination therapies.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Antimicrobial resistance is a growing global health threat.
- Antineoplastic agents are used in cancer treatment.
- Interactions between these drug classes are not fully understood.
Purpose of the Study:
- To evaluate the in-vitro synergistic and antagonistic interactions between selected antimicrobial and antineoplastic agents.
- To determine the frequency of these interactions against clinical isolates of Gram-negative bacilli.
Main Methods:
- Chequerboard dilution method was employed.
- 108 clinical isolates of four Gram-negative bacilli species were used.
- Four antimicrobial agents (piperacillin, dibekacin, minocycline, norfloxacin) and four antineoplastic agents (mitomycin C, bleomycin, doxorubicin, 5-fluorouracil) were tested.
Main Results:
- Piperacillin demonstrated the highest degree of synergism among antimicrobials; norfloxacin showed the least.
- 5-fluorouracil was more frequently synergistic against Pseudomonas aeruginosa compared to other antineoplastics.
- Synergism was most common against Proteus vulgaris and least against Escherichia coli.
- Antagonistic interactions were observed infrequently.
Conclusions:
- Combination therapy with certain antimicrobial and antineoplastic agents may be beneficial.
- Piperacillin exhibits promising synergistic potential in combination regimens.
- Further research is warranted to explore clinical applications of observed synergistic interactions.