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Updated: Jan 25, 2026
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Resolution of giant ocular surface squamous neoplasia with topical 5-fuorouracil 1
Karim Mohamed-Noriega1, Alan Baltazar Treviño-Herrera1, Abraham Olvera-Barrios1
1Department of Ophthalmology, Faculty of Medicine, University Hospital "Dr. Jose Eleuterio Gonzalez," Autonomous University of Nuevo Leon (UANL), Monterrey, Mexico.
Abstract:
An 82-year-old man presented with a left eye elevated single ocular surface squamous neoplasia. The tumor involved 360° of limbus, three quadrants of cornea and conjunctiva; this was compatible with the diagnosis of giant ocular surface squamous neoplasia. Topical 5-fluorouracil 1% was planned four times daily for 1 week followed by 3 weeks off-treatment. Patient inadvertently continued 5-fluorouracil, four times daily for 4 weeks, presenting with clinical resolution of the ocular surface squamous neoplasia and subtotal corneal epithelial defect associated with 5-fluorouracil toxicity. One month later, we observed a transparent cornea and no signs of toxicity. Total tumor resolution was observed for at least 6 months of follow-up.
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