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Updated: Jan 25, 2026

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Gas-Phase Conversion of 1,3-Dithiolane-2-Thione Into 1,3-Dithiolan-2-One Over Molybdenum Trioxide
R Alan Aitken1, Thomasine E Curzon1, Matthew J Andrews1
1EaStCHEM School of Chemistry, University of St Andrews, St Andrews, United Kingdom.
Abstract:
Gas-phase reaction of 1,3-dithiolane-2-thione over molybdenum trioxide supported on pumice stone results in efficient conversion into 1,3-dithiolan-2-one. The solid reagent is regenerated on exposure to air and thus acts as a catalyst for the overall conversion of the thione and oxygen from the air into the ketone and sulfur dioxide. The process can be carried out under either dynamic vacuum or atmospheric pressure flow conditions and using a solid reagent prepared either by physical mixing of MoO3 with the support or by solution impregnation, with an isolated yield of up to 67% obtained.
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