Related Experiment Video
Updated: Jan 25, 2026
12:16
Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells
Published on: December 17, 2015
27.0K
Porphyromonas gingivalis and digestive system cancers
1Comprehensive Laboratory, the Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China.
World Journal of Clinical Cases
|April 27, 2019
Summary
Porphyromonas gingivalis (P. gingivalis), linked to periodontal disease, is increasingly associated with digestive system cancers. This review explores P. gingivalis
Area of Science:
- Microbiology
- Oncology
- Gastroenterology
Background:
- Porphyromonas gingivalis (P. gingivalis) is an anaerobic gram-negative bacterium associated with periodontal disease.
- Emerging evidence links P. gingivalis to various digestive system cancers, including oral, esophageal, and pancreatic cancers.
Purpose of the Study:
- To review the association between P. gingivalis and digestive system tumors.
- To elucidate the effects of periodontal disease on cancer development.
- To discuss prevention, treatment, and carcinogenic mechanisms.
Main Methods:
- Literature review of clinical and experimental studies.
- Analysis of P. gingivalis' role in epithelial cell apoptosis and signaling pathways.
- Investigation of bacterial metabolism of carcinogenic substances.
Main Results:
- P. gingivalis infection is linked to oral, esophageal, and pancreatic cancers.
- The bacterium inhibits epithelial cell apoptosis, aiding cancer cell survival.
- P. gingivalis activates signaling pathways involved in tumorigenesis and immune evasion.
Conclusions:
- P. gingivalis is a significant factor in digestive system carcinogenesis.
- Understanding its mechanisms can lead to novel prevention and treatment strategies.
- Targeting P. gingivalis may offer a new approach to managing these cancers.
Related Concept Videos
00:57Carbohydrate Digestion
122.1K
Carbohydrate digestion and metabolism break down simple and complex carbohydrates from food into saccharides (i.e., sugars) for the body to use as energy. Carbohydrate digestion starts in the mouth during mastication, or chewing. The masticated carbohydrates remain intact in the stomach. Digestion resumes in the duodenum of the small intestine, where pancreatic alpha-amylase and brush border enzymes of the microvilli convert complex carbohydrates to monosaccharides. Finally, the monosaccharides...
122.1K
01:50What is Monogastric Digestion?
75.2K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
75.2K
01:06Lipid Digestion
99.0K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
99.0K
01:02Protein Digestion
110.8K
Protein digestion begins in the stomach, where the highly acidic environment can easily disrupt protein structure by exposing the peptide bonds of polypeptide chains. After polypeptide chains are broken into individual amino acids by a series of digestive enzymes, the amino acids are transported to the liver via the bloodstream to produce energy.
110.8K
01:25Regulation of the Digestive System
3.1K
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of...
The effectors in this regulation system are glands and smooth muscles. Activation of...
3.1K
01:30Other Disorders of Digestive System
1.4K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.4K