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Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

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Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Related Experiment Video

Updated: Jan 25, 2026

A Method for Islet Transplantation to the Omentum in Mouse
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Islet Transplantation in Children.

Khalid Khan1, Chirag S Desai2

  • 1Transplant Institute, MedStar Georgetown University Hospital, 3800 Reservoir Rd, Washington, DC, 20007, USA. Khalid.m.khan@gunet.georgetown.edu.

Current Gastroenterology Reports
|April 27, 2019
PubMed
Summary

Pancreas and islet transplantation in children can restore blood sugar control. Autologous islet transplantation after pancreas removal effectively manages chronic pancreatitis pain and preserves endocrine function, improving quality of life.

Keywords:
AllogenicAutologousPancreatectomy

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Area of Science:

  • Pediatric surgery
  • Endocrinology
  • Transplantation medicine

Background:

  • Chronic pancreatitis in children often stems from genetic mutations, leading to exocrine and endocrine dysfunction.
  • Pancreatic surgery and islet transplantation are critical interventions for managing debilitating symptoms and restoring metabolic balance.

Purpose of the Study:

  • To review islet and pancreas transplantation in pediatric patients.
  • To evaluate the efficacy of autologous islet transplantation following total pancreatectomy for chronic pancreatitis in children.

Main Methods:

  • Review of current literature on islet and pancreas transplantation in pediatric populations.
  • Analysis of outcomes for total pancreatectomy combined with autologous islet transplantation in children.

Main Results:

  • Autologous islet transplantation post-pancreatectomy effectively alleviates pain and preserves endocrine function in pediatric chronic pancreatitis.
  • Allogeneic islet transplantation shows promise as a future alternative to pancreas transplantation.
  • Total pancreatectomy with autologous islet transplantation in children yields excellent outcomes, including improved quality of life.

Conclusions:

  • Total pancreatectomy with autologous islet transplantation is a highly effective treatment for pediatric chronic pancreatitis.
  • Islet transplantation represents a significant advancement in managing endocrine dysfunction in children with pancreatic diseases.