Related Experiment Video
Updated: Jan 25, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
Towards Better Understanding of KSHV Life Cycle: from Transcription and Posttranscriptional Regulations to
Lijun Yan1, Vladimir Majerciak2, Zhi-Ming Zheng3
1State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.
Abstract:
Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8 (HHV-8), is etiologically linked to the development of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. These malignancies often occur in immunosuppressed individuals, making KSHV infection-associated diseases an increasing global health concern with persistence of the AIDS epidemic. KSHV exhibits biphasic life cycles between latent and lytic infection and extensive transcriptional and posttranscriptional regulation of gene expression. As a member of the herpesvirus family, KSHV has evolved many strategies to evade the host immune response, which help the virus establish a successful lifelong infection. In this review, we summarize the current research status on the biology of latent and lytic viral infection, the regulation of viral life cycles and the related pathogenesis.
More Related Videos
Related Concept Videos
The Angiosperm Life Cycle
Master Transcription Regulators
Master Transcription Regulators
Cooperative Binding of Transcription Regulators
Cooperative Binding of Transcription Regulators
Retrovirus Life Cycles

