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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
Chronic total occlusion or non-chronic total occlusion percutaneous coronary intervention: Do myocytes really care?
Arun Kalyanasundaram1, Ashok Seth1
1Cardiovascular Sciences & Interventional Cardiology, Fortis Escorts Heart Institute, New Delhi, India.
Insights
Chronic total occlusions (CTO) cause larger perfusion defects than non-CTO lesions. CTO percutaneous coronary intervention (PCI) significantly improves blood flow and reduces defect size, comparable to non-CTO PCI.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Myocardial Perfusion Imaging
Background:
- Chronic total occlusions (CTO) represent a significant challenge in coronary artery disease.
- CTO lesions are associated with larger myocardial perfusion defects compared to non-CTO lesions.
- Percutaneous coronary intervention (PCI) is a key revascularization strategy for coronary artery disease.
Abstract:
Chronic total occlusions subtend a more extensive perfusion defect size compared to non-chronic total occlusion lesions. Chronic total occlusion percutaneous coronary intervention (CTO PCI) results in significant improvement in myocardial blood flow and reduction in perfusion defect size. Improvement in hyperemic myocardial blood Flow (MBF), coronary flow reserve (CFR) and perfusion defect size is comparable in CTO and hemodynamically significant non-CTO PCI.
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