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Updated: Jan 25, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
Published on: June 20, 2015
Therapeutic targeting of gastrointestinal cancer stem cells
Jonathan Stem1, John C Flickinger2, Dante Merlino2
1Departments of Surgery, Sidney, 1020 Locust St, JAH368, Philadelphia, PA 19107, USA.
Abstract:
Gastrointestinal cancers remain a tremendous burden on society. Despite advances in therapy options, including chemotherapy and radiation, cancer mortality from recurrences and metastases occur frequently. Cancer stem cells (CSCs) drive disease recurrence and metastasis, as these cells are uniquely equipped to self-renew and evade therapy. Therefore, cancer eradication requires treatment strategies that target CSCs in addition to differentiated cancer cells. This review highlights current literature on therapies targeting CSCs in gastrointestinal cancer.
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