Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Metabolism?00:52

What is Metabolism?

131.5K
Overview
131.5K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

13.9K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.9K
Metabolic Rate01:25

Metabolic Rate

1.2K
The human body is a powerhouse of energy, with every cell performing numerous functions that require energy. This energy production and consumption is measured by the metabolic rate, which quantifies the total heat generated by all the body's chemical reactions and mechanical work. This measurement helps to determine the rate of kilocalorie (kcal) consumption needed to fuel all ongoing activities.
The Basal Metabolic Rate (BMR) measures the energy expended at rest.
Several factors influence...
1.2K
Overview of Metabolism01:40

Overview of Metabolism

37.8K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
37.8K
Regulation of Metabolism01:19

Regulation of Metabolism

11.4K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.4K
Introduction to Metabolism01:30

Introduction to Metabolism

2.7K
Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Methicillin-resistant <i>Staphylococcus aureus</i> has phenotypic variation in <i>mecA</i> expression that alters antibiotic sensitivity.

Antimicrobial agents and chemotherapy·2026
Same author

Methicillin-Resistant <i>Staphylococcus aureus</i> has Phenotypic Variation in <i>mecA</i> Expression that Alters Antibiotic Sensitivity.

bioRxiv : the preprint server for biology·2025
Same author

Glucose transporter 1 is essential for the resolution of methicillin-resistant S. aureus skin and soft tissue infections.

Cell reports·2024
Same author

Microbiota and metabolic adaptation shape <i>Staphylococcus aureus</i> virulence and antimicrobial resistance during intestinal colonization.

bioRxiv : the preprint server for biology·2024
Same author

Quorum-sensing <i>agr</i> system of <i>Staphylococcus aureus</i> primes gene expression for protection from lethal oxidative stress.

eLife·2024
Same author

The contribution of DNA repair pathways to <i>Staphylococcus aureus</i> fitness and fidelity during nitric oxide stress.

mBio·2023

Related Experiment Video

Updated: Jan 25, 2026

A Rapid Image-based Bacterial Virulence Assay Using Amoeba
05:22

A Rapid Image-based Bacterial Virulence Assay Using Amoeba

Published on: June 27, 2018

8.6K

Virulence and Metabolism.

Anthony R Richardson1

  • 1Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219.

Microbiology Spectrum
|April 27, 2019
PubMed
Summary
This summary is machine-generated.

Staphylococcus aureus virulence is influenced by its metabolic state. Understanding nutrient acquisition and energy production reveals how metabolism impacts virulence factor regulation and pathogenesis.

More Related Videos

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
06:57

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

8.7K
Metabolic Profile Analysis of Zebrafish Embryos
05:41

Metabolic Profile Analysis of Zebrafish Embryos

Published on: January 14, 2013

20.5K

Related Experiment Videos

Last Updated: Jan 25, 2026

A Rapid Image-based Bacterial Virulence Assay Using Amoeba
05:22

A Rapid Image-based Bacterial Virulence Assay Using Amoeba

Published on: June 27, 2018

8.6K
In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
06:57

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

8.7K
Metabolic Profile Analysis of Zebrafish Embryos
05:41

Metabolic Profile Analysis of Zebrafish Embryos

Published on: January 14, 2013

20.5K

Area of Science:

  • Microbiology
  • Molecular Biology
  • Biochemistry

Background:

  • Staphylococcus aureus is a highly pathogenic bacterium.
  • Its pathogenicity relies on virulence factors regulated by transcription factors.
  • The interplay between S. aureus metabolism and virulence regulation is increasingly recognized.

Purpose of the Study:

  • To review recent advances in Staphylococcus aureus metabolism concerning virulence.
  • To connect metabolic state with virulence factor regulation and pathogenesis.

Main Methods:

  • Review of nutrient acquisition mechanisms (carbohydrates, non-carbohydrate sources, micronutrients).
  • Discussion of energy production strategies (respiration vs. fermentation) in pathogenesis.
  • Outline of transcriptional regulators coordinating metabolic gene expression and their link to virulence regulators.

Main Results:

  • S. aureus acquires diverse nutrient and energy sources.
  • Metabolic strategies like respiration and fermentation are linked to pathogenesis.
  • Metabolic regulators influence key virulence factor regulators.

Conclusions:

  • The metabolic status of S. aureus significantly impacts its virulence.
  • Metabolism is a critical factor in S. aureus pathogenesis, beyond just virulence factors.
  • Targeting metabolic pathways could offer new therapeutic strategies against S. aureus infections.