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Updated: Jan 25, 2026

Using Microfluidic Devices to Measure Lifespan and Cellular Phenotypes in Single Budding Yeast Cells
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Novel disposable cell block processing device and method for high cellular yield.

Anjali Saqi1, Keith J Yeager2

  • 1Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.

Cancer Cytopathology
|April 27, 2019
PubMed
Summary
This summary is machine-generated.

The novel XCellent device significantly improves cell block preparation, yielding 371% more cellular material with better cytomorphology compared to HistoGel. This method streamlines processing times for cytology laboratories.

Keywords:
HistoGelXCellentcell blockcellularitycytologycytopathologydevicedisposablenovelsmall specimen

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Area of Science:

  • Cytopathology
  • Histotechnology
  • Laboratory Medicine

Background:

  • Cell blocks are crucial for ancillary studies like immunohistochemistry and molecular testing.
  • Current cell block processing methods lack standardization and often yield suboptimal cellularity.
  • A novel disposable device, XCellent, was developed using centrifugation to enhance cell collection and preservation.

Purpose of the Study:

  • To compare the cellular yield, cytomorphological detail, and processing times of the novel XCellent device with the traditional HistoGel method.
  • To evaluate the efficacy of XCellent in improving cell block preparation for diagnostic purposes.

Main Methods:

  • Split-sample testing was performed on fluid specimens (large-volume/cloudy and residual PreservCyt samples).
  • Two cell blocks (1 HistoGel, 1 XCellent) were processed per sample.
  • Cellularity and cytomorphology were assessed; processing times were recorded for bulk processing.

Main Results:

  • XCellent cell blocks were 371% more cellular than HistoGel cell blocks on average.
  • Superior cytomorphological detail was observed in XCellent preparations.
  • Bulk processing time for XCellent (11 minutes) was significantly shorter than for HistoGel (38 minutes).

Conclusions:

  • XCellent offers a superior alternative for cell block processing, providing high cellular yield and excellent cytomorphology.
  • The method integrates standard centrifugation, fitting seamlessly into existing cytology laboratory workflows.
  • XCellent addresses the limitations of current methods, enhancing diagnostic material quality and laboratory efficiency.