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Light-driven Enzymatic Decarboxylation
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Decarboxylative Fluorination of 2-Pyridylacetates

Ryouta Kawanishi1, Lacksany Phongphane1, Seiji Iwasa1

  • 1Department of Applied Chemistry and Life Science, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, 441-8580, Japan.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|April 27, 2019
PubMed
Summary

This study introduces a new catalyst-free method for synthesizing fluorinated pyridines. The process efficiently converts readily available pyridine derivatives into valuable pharmaceutical building blocks.

Keywords:
decarboxylationdifluoromethyl groupfluorinationmethyl esterpyridine

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