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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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Functions of Thyroid Hormones01:18

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Spontaneous Murine Model of Anaplastic Thyroid Cancer
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Thyrotoxicosis with concomitant thyroid cancer.

Hao Fu1, Lin Cheng1, Yuchen Jin1

  • 1Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.

Endocrine-Related Cancer
|April 27, 2019
PubMed
Summary
This summary is machine-generated.

Thyrotoxicosis and thyroid cancer co-occurrence is rare but requires prompt recognition. This review details causes, diagnosis, and management strategies for better patient outcomes.

Keywords:
hyperthyroidismthyroid cancerthyrotoxicosis

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Area of Science:

  • Endocrinology
  • Oncology
  • Internal Medicine

Background:

  • Thyrotoxicosis coexisting with thyroid cancer is uncommon, potentially leading to diagnostic delays and suboptimal treatment.
  • Understanding the interplay between these conditions is crucial for effective clinical management.

Purpose of the Study:

  • To systematically review the etiology, pathogenesis, diagnosis, and treatment of thyrotoxicosis in the context of concurrent thyroid cancer.
  • To provide comprehensive guidance for clinicians managing this complex clinical scenario.

Main Methods:

  • Literature review of available studies on thyrotoxicosis and thyroid cancer.
  • Categorization of etiologies, elucidation of causal mechanisms.
  • Assessment of diagnostic tools including biochemical tests, imaging, and fine-needle aspiration.
  • Evaluation of therapeutic strategies.

Main Results:

  • Etiologies include Graves' disease, Marine-Lenhart Syndrome, Plummer's disease, amiodarone-induced thyrotoxicosis, and hyperfunctioning metastases.
  • Accurate diagnosis relies on integrated clinical, biochemical, imaging, and pathological assessments.
  • Surgery is a primary treatment for both conditions, supplemented by various medical and radiological therapies.

Conclusions:

  • Prompt diagnosis and tailored treatment are essential for managing thyrotoxicosis with concurrent thyroid cancer.
  • A multidisciplinary approach integrating various treatment modalities improves prognosis.