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Updated: Jan 25, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Role of Metabolic Reprogramming in Epithelial⁻Mesenchymal Transition (EMT)
Hyunkoo Kang1, Hyunwoo Kim2, Sungmin Lee3
1Department of Integrated Biological Science, Pusan National University, Busan 46241, Korea. kanghk94@gmail.com.
Abstract:
Activation of epithelial-mesenchymal transition (EMT) is thought to be an essential step for cancer metastasis. Tumor cells undergo EMT in response to a diverse range of extra- and intracellular stimulants. Recently, it was reported that metabolic shifts control EMT progression and induce tumor aggressiveness. In this review, we summarize the involvement of altered glucose, lipid, and amino acid metabolic enzyme expression and the underlying molecular mechanisms in EMT induction in tumor cells. Moreover, we propose that metabolic regulation through gene-specific or pharmacological inhibition may suppress EMT and this treatment strategy may be applied to prevent tumor progression and improve anti-tumor therapeutic efficacy. This review presents evidence for the importance of metabolic changes in tumor progression and emphasizes the need for further studies to better understand tumor metabolism.
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