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Updated: Jan 25, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Transfeminine Hormone Therapy
Oksana Hamidi1, Caroline J Davidge-Pitts2
1Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, 2001 Inwood Road, Dallas, TX 75235, USA.
Abstract:
Transgender women often seek hormone therapy to attain feminine physical features congruent with their gender identity. The aim of feminizing hormone therapy (FHT) is to provide suppression of endogenous testosterone and to maintain estradiol levels within the normal female range. Overall, FHT is safe if provided under supervision of an experienced health care provider and has been shown to improve quality of life. Data on care of transgender women are scarce and high-quality evidence-based recommendations are lacking. This article aims to review the published literature on FHT and provide guidance to clinicians caring for transgender women.
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