Related Experiment Video
Updated: Jan 25, 2026

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model
Published on: February 14, 2025
Aortic Coarctation/Arch Hypoplasia Repair: How Small Is Too Small
Victor Tsang1, Henri Haapanen2, Ralph Neijenhuis1
1Cardiothoracic Surgery Unit, Great Ormond Street Hospital for Children, London, United Kingdom.
Abstract:
Aortic coarctation/arch hypoplasia is a relatively common congenital heart disease that leads to severe cardiovascular complications if left untreated. During the modern era, the mortality of the primary surgical repair is very low but the long-term issues, such as recurrent coarctation/arch reobstruction and hypertension, are still significant challenges. The former is related to the surgical repair performed particularly in the management of the smallish distal aortic arch, and for the latter, despite the "successful" repair of the aortic coarctation, the intrinsic vascular anomaly remains a significant long-term morbidity.
Related Concept Videos
The Arch of Aorta
Encircling the heart, the coronary arteries form a ring-like structure before...
Mismatch Repair
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Overview of DNA Repair
Chemically...
Base Excision Repair
The first step of...
Nucleotide Excision Repair

