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Updated: Jan 25, 2026

Generation of Multicellular Human Primary Endometrial Organoids
Published on: October 4, 2019
Co-localization of Coagulation Factor X and its Inhibitory System, PZ/ZPI, in Human Endometrial Cancer Tissue
Ewa Sierko1,2, Ewa Zabrocka3, Krystyna Ostrowska-Cichocka4
1Department of Oncology, Medical University, Bialystok, Poland ewa.sierko@iq.pl.
Background/Aim:
Hemostatic system components contribute to cancer progression independently from their roles in hemostasis. It has been shown that protein Z (PZ)/protein Z-dependent protease inhibitor (ZPI) inhibit coagulation factor X (FX). The aim of the study was to analyze the expression of PZ/ZPI in relation to the main coagulation factor - FX in human endometrial cancer tissue.
Materials And Methods:
Immunohistochemical analysis was performed on 21 endometrial cancer specimens employing antibodies against ZPI, PZ and FX.
Results:
Endometrial cancer cells showed a strong expression of ZPI and PZ and medium expression of FX. Normal endometrial tissue showed no expression of ZPI, PZ or FX.
Conclusion:
Strong expression of PZ and ZPI in endometrial cancer cells suggests a role of these proteins in endometrial cancer.
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