Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Basic Postulates of Kinetic Molecular Theory: Particle Size, Energy, and Collision02:43

Basic Postulates of Kinetic Molecular Theory: Particle Size, Energy, and Collision

37.5K
The ideal-gas equation, which is empirical, describes the behavior of gases by establishing relationships between their macroscopic properties. For example, Charles’ law states that volume and temperature are directly related. Gases, therefore, expand when heated at constant pressure. Although gas laws explain how the macroscopic properties change relative to one another, it does not explain the rationale behind it.
37.5K
Precipitate Formation and Particle Size Control01:16

Precipitate Formation and Particle Size Control

6.3K
In precipitation gravimetry, the precipitating agent should react specifically or selectively with the analyte. While a specific reagent reacts with the analyte alone, a selective reagent can react with a limited number of chemical species.
The obtained precipitate should be either a pure substance of known composition or easily converted to one by a simple process, such as ignition or drying. In addition, the precipitate should be insoluble and easily filterable. In general, filterability...
6.3K
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

1.6K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.6K
Motion Of A Charged Particle In A Magnetic Field01:22

Motion Of A Charged Particle In A Magnetic Field

6.8K
A charged particle experiences a force when moving through a magnetic field. Consider the field to be uniform and the charged particle to move perpendicular to it. If the field is in a vacuum, the magnetic field is the dominant factor determining the motion. Since the magnetic force is perpendicular to the direction of motion, a charged particle follows a curved path. The particle continues to follow this curved path until it forms a complete circle. Another way to look at this is that the...
6.8K
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

160
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
160
Subatomic Particles03:37

Subatomic Particles

112.6K
Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom.
112.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep learning for restoring MPI system matrices using simulated training data.

Physics in medicine and biology·2026
Same author

Continuous Coagulation Monitoring in Human Blood Samples via Magnetic Particle Spectroscopy.

International journal of nanomedicine·2026
Same author

Simple-to-Fabricate and Water-Stable Instrument Markers for Preclinical Magnetic Particle Imaging and Magnetic Resonance Imaging.

Medical devices (Auckland, N.Z.)·2026
Same author

Multi-contrast magnetic particle imaging for tomographic pH monitoring using stimuli-responsive hydrogels.

Communications engineering·2026
Same author

NMR relaxometry probes solvent-polarity-dependent molecular interactions in stimuli-responsive lyogels.

Physical chemistry chemical physics : PCCP·2025
Same author

Superferromagnetic Disk Particles for Magnetic Particle Imaging.

Small methods·2025
Same journal

Kat5 deficiency in alveolar type II cells licenses STAT6-driven glycolytic reprogramming and pulmonary fibrosis.

Nature communications·2026
Same journal

Continuous nonthermal slab gap formed by progressive tearing beneath Northeast Asia.

Nature communications·2026
Same journal

Zeolitic isolated protonic acid sites-mediated NH<sub>3</sub> storage for robust NO<sub>x</sub> removal.

Nature communications·2026
Same journal

Coaxially nested component with asymmetric fiber resonant cavity and separation membrane for gaseous and dissolved gases detection.

Nature communications·2026
Same journal

Near-unity charge readout signal in a nonlinear resonator without matching the sensor dissipation.

Nature communications·2026
Same journal

Prokaryotic Schlafen proteins cleave tRNAs during type III CRISPR immunity.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Jan 25, 2026

Application of Voltage in Dynamic Light Scattering Particle Size Analysis
07:51

Application of Voltage in Dynamic Light Scattering Particle Size Analysis

Published on: January 24, 2020

10.4K

Human-sized magnetic particle imaging for brain applications.

M Graeser1,2, F Thieben3,4, P Szwargulski3,4

  • 1Section for Biomedical Imaging, University Medical Center Hamburg-Eppendorf, 20251, Hamburg, Germany. matthias.graeser@tuhh.de.

Nature Communications
|April 28, 2019
PubMed
Summary
This summary is machine-generated.

We developed a human-scale magnetic particle imaging device for quantitative brain perfusion assessment. This sensitive imager can detect low iron concentrations, aiding in diagnosing and monitoring vascular diseases like stroke.

More Related Videos

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
07:01

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples

Published on: June 9, 2016

9.9K
Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
06:44

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

8.0K

Related Experiment Videos

Last Updated: Jan 25, 2026

Application of Voltage in Dynamic Light Scattering Particle Size Analysis
07:51

Application of Voltage in Dynamic Light Scattering Particle Size Analysis

Published on: January 24, 2020

10.4K
Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
07:01

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples

Published on: June 9, 2016

9.9K
Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
06:44

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

8.0K

Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Neuroscience

Background:

  • Accurate brain perfusion assessment is crucial for diagnosing and managing vascular diseases like stroke.
  • Post-treatment complications such as restenosis and rebleeding necessitate continuous patient monitoring.
  • Current imaging techniques may have limitations in sensitivity or accessibility for intensive care settings.

Purpose of the Study:

  • To present a novel diagnostic tomographic imager for quantitative brain perfusion analysis.
  • To demonstrate the device's capability for rapid, quantitative brain perfusion measurements.
  • To explore the potential of magnetic particle imaging (MPI) for clinical neurological applications.

Main Methods:

  • Development of a human-scale magnetic particle imaging (MPI) device.
  • Utilizing MPI technology for quantitative assessment of brain perfusion.
  • Achieving high sensitivity for detecting low iron concentrations.

Main Results:

  • The developed MPI imager enables quantitative brain perfusion measurements at short intervals.
  • The device exhibits high sensitivity, detecting iron concentrations as low as 263 pmolFe/ml.
  • The imager is self-shielded, allowing operation in unshielded environments like intensive care units.

Conclusions:

  • The novel MPI imager offers a promising tool for quantitative brain perfusion assessment.
  • Its high sensitivity and portability facilitate early diagnosis and continuous monitoring of cerebrovascular diseases.
  • This technology has the potential to significantly improve stroke monitoring in intensive care units.