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Renin-angiotensin system research: from molecules to the whole body

Eriko Takimoto-Ohnishi1,2, Kazuo Murakami3

  • 1Bio-Laboratory, Foundation for Advancement of International Science, 3-24-16 Kasuga, Tsukuba, Ibaraki, 305-0821, Japan. onishi-e@ncchd.go.jp.

The Journal of Physiological Sciences : JPS
|April 28, 2019
PubMed

Insights

Researchers investigated the molecular mechanisms of the renin-angiotensin system (RAS) in hypertension. They developed genetically modified mice to study this key hormonal pathway involved in blood pressure regulation.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Genetics

Background:

  • Hypertension is a major risk factor for cardiovascular and cerebrovascular diseases.
  • The renin-angiotensin system (RAS) plays a critical role in hypertension development.
  • Detailed molecular mechanisms of RAS in vivo remain incompletely understood.

Purpose of the Study:

  • To elucidate the in vivo molecular mechanisms of the renin-angiotensin system (RAS) in hypertension.
  • To investigate the role of specific genes within the RAS pathway.

Main Methods:

  • Creation of transgenic mice with human renin and angiotensinogen genes for chronic hypertension.
  • Development of hypotensive mice with targeted disruption of the angiotensinogen gene.
  • Review of 47 years of research on the renin-angiotensin system.

Main Results:

  • Genetically engineered mouse models were successfully created to study hypertension.
  • These models allow for in-depth investigation of RAS components and their effects on blood pressure.
  • The research provides insights into the complex interplay of genetic and environmental factors in hypertension.

Conclusions:

  • Transgenic mouse models are valuable tools for understanding RAS in hypertension.
  • Further research into RAS molecular mechanisms can lead to improved hypertension therapies.
  • This work highlights the significance of the renin-angiotensin system in blood pressure regulation.

Keywords:
AngiotensinogenHypertensionKnockout miceReninRenin–angiotensin systemTransgenic mice

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