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A compendium of current developments on polysaccharide and protein-based microneedles
Daniela F S Fonseca1, Carla Vilela1, Armando J D Silvestre1
1CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
International Journal of Biological Macromolecules
|April 28, 2019
Summary
Biopolymer microneedles (MNs) made from polysaccharides and proteins offer a sustainable and biocompatible platform for transdermal drug delivery. These advanced MNs show great potential for drug administration, sensing, and clinical translation.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Microneedles (MNs) are minimally invasive microstructures for transdermal drug delivery.
- Biopolymers like polysaccharides and proteins are increasingly used for MN fabrication due to their biocompatibility and sustainability.
Purpose of the Study:
- To provide a comprehensive review of polysaccharide and protein-based MNs.
- To discuss fabrication strategies, advantages, disadvantages, and applications of these biopolymer MNs.
Main Methods:
- Literature review focusing on polysaccharide and protein-based microneedle technology.
- Analysis of fabrication methods, material properties, and therapeutic potential.
Main Results:
- Polysaccharide and protein MNs offer tunable properties and functionalities for advanced applications.
- These biopolymer MNs show significant potential in drug delivery, vaccines, and biosensing.
Conclusions:
- Biopolymer-based MNs represent a promising next-generation platform for drug delivery and other biomedical applications.
- Further research and development are crucial for the clinical translation of these innovative microneedle systems.
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