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Updated: Jan 25, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
Unidentified cachexia patients in the oncologic setting: Cachexia UFOs do exist
Elisabeth De Waele1, Joy Demol1, Riccardo Caccialanza2
1Intensive Care Unit, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium; Department of Nutrition, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Cancer cachexia is often undiagnosed in newly diagnosed patients, with nutritional interventions lacking. This highlights a gap in care, impacting patient outcomes and the success of nutritional therapy trials.
Area of Science:
- Oncology
- Clinical Nutrition
- Patient Outcomes
Background:
- Cachexia significantly impacts cancer patient outcomes.
- Early identification and management of cachexia are crucial for effective cancer care.
- The TiCaCONCO trial aimed to improve nutritional therapy in cachectic cancer patients.
Purpose of the Study:
- To retrospectively analyze patient charts for data on body weight, nutritional status, and interventions in cancer patients.
- To identify the prevalence of cachexia at diagnosis and the extent of nutritional interventions by oncologists and dietitians.
Main Methods:
- Retrospective chart review of 9694 patient files in a tertiary oncology setting over 8 months.
- Data collected included patient characteristics, tumor type, body weight, nutritional status, and documented interventions.
- Screening focused on patients admitted to oncology, gastroenterology, or abdominal surgery units.
Main Results:
- Cachexia was present in 42% of newly diagnosed cancer patients, but nutritional information was missing for 46% of patients.
- Only 16% of cachectic patients received physician-initiated nutritional interventions, and 9% overall had documented interventions.
- Dietitians documented nutrition and weight for 42% of patients.
Conclusions:
- Newly diagnosed cancer patients are not systematically identified for cachexia, and nutritional interventions are insufficient.
- Barriers between oncologists and dietitians hinder effective nutritional therapy and trial success.
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