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Updated: Jan 25, 2026

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
11:39

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

21.0K

Changes in hemodynamics, cerebral oxygenation and cerebrovascular reactivity during the early transitional

Cristine Sortica da Costa1, Danilo Cardim2, Zoltan Molnar3

  • 1Neonatal Unit, The Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. csortica@cantab.net.

Pediatric Research
|April 28, 2019
PubMed

Insights

Systemic and cerebral blood flow dynamics in preterm infants differ with intraventricular hemorrhage (IVH). Infants with IVH showed lower cerebral oxygenation and altered cerebrovascular reactivity.

Area of Science:

  • Neonatal physiology
  • Cerebrovascular regulation
  • Hemodynamic monitoring

Background:

  • Systemic and cerebral hemodynamics in preterm infants are complex during transitional circulation.
  • These hemodynamic patterns may vary in infants with and without intraventricular hemorrhage (IVH).

Purpose of the Study:

  • To investigate and compare systemic and cerebral hemodynamic changes in preterm infants with and without IVH.
  • To assess tissue oxygenation and cerebrovascular reactivity in relation to IVH development.

Main Methods:

  • Continuous near-infrared spectroscopy (NIRS) monitoring of tissue oxygenation index (TOI) and cerebrovascular reactivity in 43 preterm infants within 48 hours of birth.
  • Left and right cardiac outputs (LVO, RVO) and patent ductus arteriosus (PDA) measurements were collected at multiple time points.

Main Results:

  • Left ventricular output (LVO) increased in both IVH and no-IVH groups, with similar patterns of change between groups.
  • Tissue oxygenation index (TOI) was significantly lower in the IVH group.
  • A positive correlation was observed between TOI and LVO, and a negative correlation between tissue oxygen reactivity index (TOx) and LVO at 24 hours in the IVH group.

Conclusions:

  • Preterm infants who develop IVH exhibit lower cerebral oxygenation at 24 hours of life.
  • Cerebrovascular reactivity in these infants becomes passive in response to systemic blood flow changes.
Abstract

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