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Eosinophilic Granulomatosis with Polyangiitis in a 4-Year-Old Child: Is Montelukast and/or Clarithromycin a Trigger?
Esma Altinel Acoglu1, Fatma Yazilitas2, Asuman Gurkan3
1Department of Pediatrics, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
Insights
This case study explores the link between eosinophilic granulomatosis with polyangiitis (EGPA) and medications like montelukast and clarithromycin. Early recognition and treatment are crucial for children with asthma and hypereosinophilia.
Area of Science:
- Pediatric Rheumatology
- Pulmonology
- Clinical Pharmacology
Background:
- Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare autoimmune vasculitis.
- Asthma and hypereosinophilia are common in pediatric EGPA cases.
- Association of EGPA with leukotriene receptor antagonists and macrolides requires further investigation.
Abstract:
The aim of the presentation of this case is to discuss whether there is an association with eosinophilic granulomatosis with polyangiitis (EGPA) and the use of montelukast, and clarithromycin and to discuss a successful treatment course. A 4-year-old girl with a preceding history of asthma attacks and increased eosinophil counts was admitted. She had been using clarithromycin for five days and montelucast for a month. She was eventually diagnosed with EGPA with detailed examination. Clinicians should remember EGPA in children with asthma and hypereosinophilia. Patients receiving leukotriene receptor antagonists and/or macrolides should be monitored for developing a multisystem disease. Treatment with immunosuppressive agents may be required to ensure a good prognosis.
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