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Related Experiment Video

Updated: Jan 25, 2026

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

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Topiramate: Comprehensive profile.

Nasr Y Khalil¹, Haitham K AlRabiah¹, Saad S Al Rashoud¹

¹Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology

|April 29, 2019

Summary

This summary is machine-generated.

Topiramate is an antiepileptic drug effective for seizures and migraine prevention. Its weight loss effects led to approval as an anti-obesity medication, potentially via carbonic anhydrase inhibition.

Keywords:

Analytical methods Antiepileptic Pharmacokinetics Preparation method Thermal and spectral behavior Topiramate

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Area of Science:

Pharmacology
Neuroscience
Metabolic Disorders

Background:

Topiramate is a sulfamate-substituted derivative of the monosaccharide D-fructose.
It exhibits broad-spectrum anticonvulsant activity against various seizure types.

Purpose of the Study:

To provide a comprehensive profile of topiramate, including its physical and chemical properties.
To discuss its pharmacological actions, pharmacokinetics, and therapeutic applications.

Main Methods:

Review of existing literature on topiramate's properties, efficacy, and safety.
Analysis of its mechanism of action, including carbonic anhydrase inhibition.
Discussion of analytical methods and pharmacokinetic profiles.

Main Results:

Topiramate is effective for partial and generalized seizures and migraine prevention.
Common adverse events include paresthesia, fatigue, and decreased appetite.
Observed weight loss in obese epileptic patients led to its approval for anti-obesity treatment.

Conclusions:

Topiramate possesses a multifaceted pharmacological profile with applications in epilepsy, migraine, and obesity.
Its efficacy is linked to the inhibition of mitochondrial carbonic anhydrase isoforms.
Understanding its characteristics is crucial for clinical application and further research.