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Related Concept Videos

Anxiety: Overview01:18

Anxiety: Overview

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Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
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Generalized Anxiety Disorder01:30

Generalized Anxiety Disorder

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Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
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Social Anxiety Disorder01:28

Social Anxiety Disorder

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Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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Related Experiment Video

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Hyponeophagia: A Measure of Anxiety in the Mouse
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Anxiety and task performance changes in an aging mouse model.

Erika D Nolte1, Keith A Nolte1, Shirley ShiDu Yan1

  • 1Department of Pharmacology and Toxicology, Higuchi Bioscience Center, University of Kansas, Lawrence, KS 66047, USA.

Biochemical and Biophysical Research Communications
|April 29, 2019
PubMed
Summary
This summary is machine-generated.

Aging impairs cognitive function in mice, particularly in females who show increased anxiety. Both sexes experience declines in daily task performance by 24 months, indicating cognitive aging without motor deficits.

Keywords:
AgingAnxietyTask performance

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Area of Science:

  • Gerontology
  • Neuroscience
  • Animal Models

Background:

  • Aging is a significant risk factor for numerous diseases.
  • Translational animal models are crucial for studying age-related conditions.
  • Understanding cognitive aging in standard mouse models is essential.

Purpose of the Study:

  • To investigate age-related behavioral and cognitive changes in non-genetically modified mice.
  • To determine sex-specific differences in cognitive decline during aging.
  • To assess the impact of aging on motor function and daily task performance.

Main Methods:

  • Utilized behavioral tests to assess anxiety-like behaviors in aging mice.
  • Evaluated cognitive function through daily task performance assessments.
  • Monitored gross motor function to differentiate from cognitive changes.

Main Results:

  • Female mice exhibited anxiety-like behaviors starting at 12 months, worsening by 24 months.
  • Male mice did not display age-induced anxiety-like behaviors.
  • Both male and female mice showed impaired performance in daily tasks at 24 months.
  • No significant changes in gross motor function were observed with aging.

Conclusions:

  • Aging leads to cognitive impairment in standard mouse models.
  • Sex differences exist in the manifestation of age-related anxiety.
  • Cognitive decline in aging mice is not associated with motor deficits.